UNIVERSITÄT ZU KÖLN

Tauopathien sind eine Gruppe neurodegenerativer Erkrankungen die zur Demenz führen. Bei manchen Tauopathien besteht auch eine Beeinträchtigung der Motorik. Die häufigste Tauopathie ist der Morbus Alzheimer. Tauopathien sind histopathologisch durch die Akkumulation des Proteins Tau in bestimmten Zelltypen und Regionen des Gehirns charakterisiert. Wir untersuchen mögliche Pathomechanismen, besonders den Zusammenhang zwischen granulovakuolärer Degeneration, einer neurodegenerativen Veränderung der Neurone, und der Tau-Pathologie.

• Histologische/Immunhistologische Untersuchung der Neurodegeneration in den Gehirnen alter Menschen

 

• Al Kabbani MA, Wunderlich G, Köhler C, Zempel H (2022): AAV-based gene therapy approaches for genetic forms of tauopathies and related neurogenetic disorders. BIOCELL, Vol.46, No.4, 847-853. doi: 10.32604/biocell.2022.018144. (Abstract)

• Puladi B, Vogt F, Dinekov M, Köhler C (2022) : Variants of arterial supply to the inferior (diaphragmatic) surface of the ventricles of the heart and the influence on age at death. Clin Anat 1-8. doi: 10.1002/ca.23846 (Abstract)

• Puladi B, Dinekov M, Arzberger T, Taubert M, Köhler C (2021): The relation between tau pathology and granulovacuolar degeneration of neurons. Neurobiol Dis 15;147:105138. doi: 10.1016/j.nbd.2020.105138. (Abstract)

• Yamoah A, Tripathi P, Sechi A, Köhler C, Guo H, Chandrasekar A, Nolte KW, Wruck CJ, Katona I, Anink J, Troost D, Aronica E, Steinbusch H, Weis J, Goswami A. J (2020) : Aggregates of RNA Binding Proteins and ER Chaperones Linked to Exosomes in Granulovacuolar Degeneration of the Alzheimer's Disease Brain. J Alzheimers Dis 2020;75(1): 139-156. doi: 10.3233/JAD-190722. (Abstract)

• Midani-Kurçak JS, Dinekov M, Puladi B, Arzberger T, Köhler C: Effect of tau-pathology on charged multivesicular body protein 2b (CHMP2B).Brain Res 2019 Mar 1;1706:224-236 (Abstract)

• Köhler C, Fuhr V, Dinekov M: Distribution of spleen tyrosine kinase and tau phosphorylated at tyrosine 18 in a mouse model of tauopathy and in the human hippocampus. Brain Res 2017 Dec 15; 1677: 1-13.doi: 10.1016/j.brainres.2017.08.029. Epub 2017 Sep (Abstract)

• Klingebiel M, Dinekov M, Köhler C.: Analysis of ribosomal protein S6 baseline phosphorylation and effect of tau pathology in the murine brain and human hippocampus. Brain Research 1659, 15 March 2017, Pages 121–135. doi: 10.1016/j.brainres.2017.01.016 (Abstract)

• Köhler C.: Granulovacuolar degeneration: a neurodegenerative change that accompanies tau pathology. Acta Neuropathol. 2016 Sep;132(3):339-59. doi: 10.1007/s00401-016-1562-0. Review. (Abstract)

• Köhler C, Dinekov M, Götz J: Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosis. Neurobiol Dis. 2014 Nov;71:169-79. doi: 10.1016/j.nbd.2014.07.006. Epub 2014 Jul 27. (Abstract)

• Köhler C, Dinekov M, Götz J: Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice. Neurobiol Aging. 2013 May;34(5):1369-79. doi: 10.1016/j.neurobiolaging.2012.11.010. Epub 2013 Jan 4. (Abstract)

• Morcinek K, Köhler C, Götz J, Schröder H: Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice. Brain Res. 2013 Feb 25;1497:73-84. doi: 10.1016/j.brainres.2012.12.016. Epub 2012 Dec 20. (Abstract)

• Köhler C. Histochemical localization of caldesmon isoforms in colon adenocarcinoma and lymph node metastases. Virchows Arch. 2011 May 29. [Epub ahead of print] DOI: 10.1007/s00428-011-1091-0 (Abstract)

• Köhler C. Histochemical localization of caldesmon in the CNS and Ganglia of the mouse. J Histochem Cytochem (2011) 59:504-17 (2011) (Abstract)

• Köhler C, Bista P, Götz J, Schröder H. Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy. Brain Res 1347:111-24 (2010) (Abstract)

• Mende Y, Jakubik M, Riessland M, Schoenen F, Roßbach K, Kleinridders A, Köhler C, Buch T, Wirth B Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN /Smn splicing. Hum Mol Genet 19:2154-67 (2010) (Abstract)

• Köhler C: The Actin-binding Protein Caldesmon Is in Spleen and Lymph Nodes Predominately Expressed by Smooth Muscle Cells, Reticular Cells, and Follicular Dendritic Cells. J Histochem Cytochem 58:183-193 (2010) (Abstract)

• Freude S, Hettich MM, Schumann C, Stöhr O, Koch L, Köhler C, Udelhoven M, Leeser U, Müller M, Kubota N, Kadowaki T, Krone W, Schröder H, Brüning JC, Schubert M: Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease. FASEB J 23:3315-24 (2009) (Abstract)

• Freude S, Leeser U, Müller M, Hettich MM, Udelhoven M, Schilbach K, Tobe K, Kadowaki T, Köhler C, Schröder H, Krone W, Brüning JC, Schubert M: IRS-2 branch of IGF-1 receptor signaling is essential for appropriate timing of myelination. J Neurochem 107:907-17 (2008) (Abstract)

• Köhler C: Allograft inflammatory factor 1 / Ionized calcium binding adapter molecule 1 is specifically expressed by most subpopulations of macrophages and spermatids in testis. Cell Tissue Res 330: 291-302 (2007) (Abstract)

• Köhler C, Ebert U, Baumann K, Schröder H: Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels. Neurobiol Dis. 20:528-540 (2005) (Abstract)

• Kinscherf R, Köhler C, Kreuter C, Pill J, Metz J: Hypercholesterolemia increases manganese superoxide dismutase immunoreactive macrophages in myocardium. Histochem Cell Biol 104: 295-300 (1995) (Abstract)

• Kinscherf R, Köhler C, Pavlov P, Pill J, Metz J: Der Einfluß der Hypercholesterinämie auf Makrophagen außerhalb arteriosklerotischer Plaques. Perfusion 8: 59 (1995)

• Metz J, Köhler C, Hefele K, Schmelz A: Ausprägung der Atherosklerose in Aorta, Koronararterien und Karotiden bei experimenteller Hypercholesterinämie. Verh. Anat. Ges. 85 (Anat. Anz. Suppl. 170): 267-268 (1991)

• Wolf O, Köhler C, Schmelz A, Pill J, Hartig F, Metz J: Pharmakologische Beeinflussung der atherosklerotischen Progression bei experimenteller Hypercholesterinämie. Verh. Anat. Ges. 85 (Anat. Anz. Suppl. 170): 265-266 (1991)

• Metz J, Hefele K, Köhler C, Pavlov P, Schmelz A: Quantitative Analyse der Atherosklerose bei experimenteller Hypercholesterinämie. Zschr. Kardiologie 79: 85 (1990)